منابع مشابه
Urinary Transforming Growth Factors in Neoplasia: Separation
Purified human epidermal growth factor (hEGF) from urine promotes anchorage-independent cell growth in soft agar medium. This growth is enhanced by transforming growth factor-/} (TGF-/8), and is specifically inhibited by hEGF antiserum. Transforming growth factors of the a type (TGF-a), potentially present in normal human urine or urine from tumorbearing patients, also promote anchorage-indepen...
متن کاملAnkylosing spondylitis, IgA, and transforming growth factors.
This hypothesis article reviews laboratory findings in seronegative arthritides with a view to discovering which cvtokines are likely to be most important in their pathogenesis. It concludes that transforming growth factors may play a significant role, and suggests that they derive from a group of T cells which have recently been rather neglected by academic immunologists. Ankylosing spondyliti...
متن کاملGrowth modulation of mouse keratinocytes by transforming growth factors.
The effects of exogenously added transforming growth factor (TGF alpha and TGF beta on the growth of BALB/MK cells were examined. TGF alpha supplanted the epidermal growth factor (EGF) requirement in these cells. In contrast, TGF beta reversibly inhibited the growth of BALB/MK cells by abrogating the stimulatory actions of EGF or TGF alpha. The inhibitory effects of TGF beta appeared to be medi...
متن کاملThe Neuroprotective Functions of Transforming Growth Factor Beta Proteins
Transforming growth factor beta (TGF-β) proteins are multifunctional cytokines whose neural functions are increasingly recognized. The machinery of TGF-β signaling, including the serine kinase type transmembrane receptors, is present in the central nervous system. However, the 3 mammalian TGF-β subtypes have distinct distributions in the brain suggesting different neural functions. Evidence of ...
متن کاملTransforming Growth Factors in Solid Human Malignant Neoplasms1
Surgically removed solid human benign and malignant neo plasms and nonneoplastic tissues were examined for the pres ence of transforming growth factors (TGFs). TGFs are polypeptide growth factor-like substances which cause the appearance of a reversible neoplastic phenotype in nontransformed, anchor age-dependent cells in culture, including the induction of the ability to grow while suspended i...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1989
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1989.tb15041.x